TMRNA Meaning and
Definition
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TMRNA, which stands for Template-Dependent, Mismatch-Recognizing, and Abortive Translation, is a molecular process found in some organisms that enables the replacement of RNA molecules within a functioning ribosome during protein synthesis. It is an essential cellular mechanism involved in maintaining the fidelity and accuracy of protein production.
During translation, the ribosome reads the genetic code on mRNA molecules to produce proteins. However, errors can occur in the mRNA sequence due to mutations or damage. TMRNA plays a crucial role in identifying and rectifying these errors. It recognizes mismatches or imperfections in the mRNA template and, instead of elongating the protein chain, it substitutes the faulty mRNA with a sequence that specifies the addition of a short stretch of amino acids called tmRNA tags.
The tmRNA molecule acts as a dual-function RNA. Its unique structure allows it to act as both a tRNA and an mRNA. Initially, it enters the ribosome complex like a tRNA, but when the ribosome encounters a problematic codon sequence, it switches itself into an mRNA-like template. The ribosome then translates the tmRNA sequence, incorporating the amino acid tag into the nascent polypeptide chain. This transition from normal translation to tmRNA-mediated translation is known as "trans-translation."
TMRNA is vital for cellular quality control mechanisms, as it helps remove incomplete or misfolded proteins and frees the ribosome for subsequent translation rounds. Moreover, it aids in the degradation of faulty mRNA molecules, preventing their re-entry into the translation process. The discovery and understanding of TMRNA have greatly contributed to the field of molecular biology and enhanced our knowledge of protein synthesis and gene regulation.
Common Misspellings for TMRNA
- rmrna
- gmrna
- 6mrna
- 5mrna
- tnrna
- tjrna
- tmtna
- tm5na
- tm4na
- tmrnz
- tmrnw
- tmrnq
- rtmrna
- trmrna
- ftmrna
- tfmrna
- gtmrna
- tgmrna
- ytmrna
- tymrna
- 6tmrna
- t6mrna
- 5tmrna
- t5mrna
- tnmrna
- tmnrna
- tkmrna
- tmkrna
- tjmrna
- tmjrna
- tmerna
- tmdrna
- tmrdna
- tmfrna
- tmrfna
- tmtrna
- tmrtna
- tm5rna
- tmr5na
- tm4rna
- tmr4na
- tmrbna
- tmrnba
- tmrmna
- tmrnma
- tmrjna
- tmrnja
- tmrhna
- tmrnha
- tmrnza
- tmrnaz
- tmrnsa
- tmrnas
- tmrnwa
- tmrnaw
- tmrnqa
- tmrnaq
- ttmrna
- tmmrna
- tmrrna
- tmrnna
- tmrnaa
- pMRNA
- TMzNA
- TMvNA
- TMpNA
- TMsNA
- TMRlA
- TMRNi
- t mrna
- tm rna
- tmr na
- tmrn a
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