TIOGUANINE Meaning and
Definition
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Tioguanine, also known by its brand name Tabloid, is a chemotherapeutic drug used in the treatment of certain types of cancers, particularly of the blood and bone marrow. It belongs to the class of medications known as antimetabolites, which work by interfering with the DNA synthesis process in rapidly dividing cells.
Tioguanine is primarily used in the treatment of acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and T-cell acute lymphoblastic leukemia (T-ALL). It may also be used in combination with other medications to treat inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, due to its immunosuppressive properties.
The mechanism of action of tioguanine involves its conversion into an active metabolite within the body, which then disrupts the synthesis of DNA and RNA by inhibiting enzymes involved in these processes. This inhibition prevents the replication and growth of cancer cells, ultimately leading to their death.
Tioguanine is administered orally in the form of tablets, typically taken once daily or as directed by a healthcare professional. Dosage may vary depending on the specific cancer being treated and individual patient factors. Some common side effects of tioguanine include bone marrow suppression, gastrointestinal disturbances, liver toxicity, and increased susceptibility to infections.
As with any medication, close monitoring and regular follow-up with a healthcare provider are necessary while taking tioguanine to ensure efficacy and minimize adverse effects.
Common Misspellings for TIOGUANINE
- rioguanine
- fioguanine
- gioguanine
- yioguanine
- 6ioguanine
- 5ioguanine
- tuoguanine
- tjoguanine
- tkoguanine
- tooguanine
- t9oguanine
- t8oguanine
- tiiguanine
- tikguanine
- tilguanine
- tipguanine
- ti0guanine
- ti9guanine
- tiofuanine
- tiovuanine
Etymology of TIOGUANINE
The word "Tioguanine" is derived from the chemical compound it represents. "Thio" refers to the presence of a sulfhydryl (thiol) group (-SH) in the molecule, and "guanine" is a nucleobase, one of the building blocks of DNA and RNA. Tioguanine, also known as 6-thioguanine, is an antimetabolite medication used in the treatment of certain types of cancer, especially leukemia.
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