STAPHYLOCOCCAL PROTEIN A Meaning and
Definition
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Staphylococcal Protein A (SPA) is a protein produced by the bacterium Staphylococcus aureus, commonly known as staph infection. It is a surface protein that plays a crucial role in the interaction between the bacterium and the host's immune system.
SPA has a high affinity for immunoglobulin G (IgG), which is a type of antibody produced by the immune system to fight against infections. It binds specifically to the Fc region of IgG, allowing it to immobilize and neutralize antibodies. By binding to the Fc region, SPA can interfere with the binding of IgG to other immune cells, thus preventing the activation of the immune response. This mechanism of immune evasion enables staphylococcus aureus to evade detection and destruction by the host's immune system.
The Fc-binding properties of SPA also make it useful in laboratory and medical applications. Researchers and clinicians employ this protein to purify and detect IgG antibodies in various tests and assays. SPA can be immobilized on solid surfaces, such as chromatography resins or microplates, to capture and isolate specific IgG antibodies for diagnostic or research purposes.
Overall, Staphylococcal Protein A is a key virulence factor produced by Staphylococcus aureus and acts as an immune evasion strategy, enabling the bacterium to evade host immune responses. Additionally, it possesses useful properties that have facilitated its usage in various scientific and clinical applications related to antibody purification and detection.
Common Misspellings for STAPHYLOCOCCAL PROTEIN A
- ataphylococcal protein a
- ztaphylococcal protein a
- xtaphylococcal protein a
- dtaphylococcal protein a
- etaphylococcal protein a
- wtaphylococcal protein a
- sraphylococcal protein a
- sfaphylococcal protein a
- sgaphylococcal protein a
- syaphylococcal protein a
- s6aphylococcal protein a
- s5aphylococcal protein a
- stzphylococcal protein a
- stsphylococcal protein a
- stwphylococcal protein a
- stqphylococcal protein a
- staohylococcal protein a
- stalhylococcal protein a
- sta-hylococcal protein a
- sta0hylococcal protein a
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