REGULATORY T LYMPHOCYTE Meaning and
Definition
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A Regulatory T Lymphocyte, commonly abbreviated as Treg cell, refers to a specialized subset of T lymphocytes or T cells that play a crucial role in modulating the immune response of an organism. These cells are responsible for maintaining immune tolerance by suppressing the activity of other immune cells and preventing excessive immune responses against self-antigens.
Regulatory T lymphocytes possess specific surface markers, including the transcription factor Foxp3, which is essential for their development and function. Their origin can be classified into two main categories: thymus-derived Treg cells and peripherally-induced Treg cells. Thymus-derived Treg cells arise during the maturation of T cells in the thymus, while peripherally-induced Treg cells are generated in peripheral tissues through the conversion of naïve T cells.
The primary role of Regulatory T lymphocytes is to prevent autoimmune diseases by inhibiting the activation and function of autoreactive T cells and other effector immune cells. They achieve this by release of anti-inflammatory cytokines like interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), as well as by direct cell-to-cell contact.
In addition to maintaining immune tolerance, Regulatory T lymphocytes also regulate immune responses against pathogens, prevent excessive inflammation, and aid in tissue repair and wound healing. Dysregulation in Regulatory T lymphocyte function has been associated with various autoimmune diseases, allergies, and cancer.
Understanding the mechanisms controlling Regulatory T lymphocyte function is important for developing therapeutic interventions to modulate immune responses in various pathological conditions.
Common Misspellings for REGULATORY T LYMPHOCYTE
- eegulatory t lymphocyte
- degulatory t lymphocyte
- fegulatory t lymphocyte
- tegulatory t lymphocyte
- 5egulatory t lymphocyte
- 4egulatory t lymphocyte
- rwgulatory t lymphocyte
- rsgulatory t lymphocyte
- rdgulatory t lymphocyte
- rrgulatory t lymphocyte
- r4gulatory t lymphocyte
- r3gulatory t lymphocyte
- refulatory t lymphocyte
- revulatory t lymphocyte
- rebulatory t lymphocyte
- rehulatory t lymphocyte
- reyulatory t lymphocyte
- retulatory t lymphocyte
- regylatory t lymphocyte
- reghlatory t lymphocyte
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