How Do You Spell PSEUDOOSTEOMALACIA?

1. Pseudoosteomalacia is a medical condition that is characterized by the presence of bone pain, weakness, and an increased risk of fractures. This condition resembles osteomalacia, which is the softening of the bones due to a deficiency of vitamin D or problems with its metabolism. However, unlike true osteomalacia, pseudoosteomalacia does not result from a lack of vitamin D, calcium, or phosphate absorption issues.

   The term "pseudo" in pseudoosteomalacia suggests that this condition is not a true form of osteomalacia. Instead, it is often caused by an underlying disorder known as tumor-induced osteomalacia (TIO). TIO involves the presence of a tumor or abnormal growth, typically in the soft tissues or bones, which produces high levels of fibroblast growth factor 23 (FGF23). FGF23 inhibits the reabsorption of phosphate by the kidneys, leading to low levels of phosphate in the blood and impaired bone mineralization.

   Individuals with pseudoosteomalacia may experience bone pain, muscle weakness, and fatigue as a result of poor bone density and strength. Due to the underlying tumor or growth, the affected bones may also be susceptible to fractures, even from minimal trauma.

   Treatment for pseudoosteomalacia generally involves identifying and removing the underlying tumor or growth responsible for the excessive production of FGF23. This can often lead to a resolution of the symptoms and improvement in bone density. In cases where the tumor cannot be removed, management may involve the use of medications to regulate phosphate metabolism and optimize bone health.

2. Rachitic softening of bone.

   A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.

Common Misspellings for PSEUDOOSTEOMALACIA

The word "pseudoosteomalacia" is formed from three roots: "pseudo-", "osteo-", and "-malacia".

1. "Pseudo-" is a prefix borrowed from the Greek language, meaning "false" or "fake". It is used to indicate something that appears to be something it is not. It is often added to a word to indicate a condition or disease that mimics or resembles a particular condition.

2. "-Osteo" is derived from the Greek word "osteon", meaning "bone". It is widely used in medical terminology to indicate a relationship with bones.

3. "-Malacia" is also derived from the Greek language, specifically from the term "malakia", meaning "softness" or "softening". It is usually added to a word to describe a pathological condition where something becomes abnormally soft.