PROTEIN KINASE G Meaning and
Definition
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Protein Kinase G (PKG) is an enzyme that belongs to the family of protein kinases and is primarily involved in cellular signaling processes. It is also referred to as cGMP-dependent protein kinase, as it is activated by cyclic guanosine monophosphate (cGMP). PKG plays a crucial role in various physiological functions, including regulating smooth muscle relaxation, blood vessel dilation, neurotransmitter release, platelet aggregation, and gene expression.
The enzyme is comprised of two subunits, a regulatory subunit and a catalytic subunit, which together form an inactive PKG molecule. Upon binding of cGMP to the regulatory subunit, it undergoes conformational changes, leading to the release of the catalytic subunit. This activated catalytic subunit then phosphorylates specific protein targets to bring about various cellular responses.
PKG has been extensively studied in the context of cardiovascular health, as it is a key mediator of blood pressure regulation and the relaxation of blood vessels. Dysregulation of PKG activity has been implicated in various diseases, including hypertension, heart failure, and erectile dysfunction. Pharmacological targeting of PKG has shown promise in the development of therapies for these conditions.
In summary, Protein Kinase G is an enzyme that is activated by cGMP and is involved in important signaling pathways throughout the body. It plays a crucial role in regulating various physiological functions and is implicated in numerous diseases. Further research on PKG may provide insights into the development of novel treatments for cardiovascular and other related disorders.
Common Misspellings for PROTEIN KINASE G
- orotein kinase g
- lrotein kinase g
- -rotein kinase g
- 0rotein kinase g
- peotein kinase g
- pdotein kinase g
- pfotein kinase g
- ptotein kinase g
- p5otein kinase g
- p4otein kinase g
- pritein kinase g
- prktein kinase g
- prltein kinase g
- prptein kinase g
- pr0tein kinase g
- pr9tein kinase g
- prorein kinase g
- profein kinase g
- progein kinase g
- proyein kinase g
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