PHOSPHONOMYCIN Meaning and
Definition
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Phosphonomycin is a noun that refers to a broad-spectrum antibiotic with potent activity against certain bacteria, particularly gram-negative bacteria. It is often used in the treatment of urinary tract infections caused by multidrug-resistant bacteria. Known by its chemical name (2R,3S)-3-epoxy-1-aminomethylphosphonic acid, phosphonomycin is primarily used as a last resort or second-line therapy due to its potential for serious adverse effects and the emergence of resistance.
The mechanism of action of phosphonomycin involves inhibiting an enzyme called enolpyruvyl transferase, which is essential for the synthesis of bacterial cell walls. By inhibiting this enzyme, phosphonomycin disrupts the production of peptidoglycan, a vital component of the bacterial cell wall. Consequently, the affected bacteria are unable to maintain their structural integrity, leading to their death.
Phosphonomycin is primarily administered intravenously or orally, depending on the severity and type of infection. Because it is excreted primarily by the kidneys, careful adjustment of dosages is necessary for patients with impaired renal functions. Common side effects associated with phosphonomycin include gastrointestinal disturbances such as nausea, diarrhea, and abdominal pain. Less frequently, allergic reactions or superinfections may occur.
While phosphonomycin has shown efficacy against certain bacterial strains, its use is limited due to the development of resistance and its potential to cause adverse effects. Therefore, it is crucial for healthcare professionals to carefully consider the risks and benefits before prescribing phosphonomycin to patients.
Common Misspellings for PHOSPHONOMYCIN
- ohosphonomycin
- lhosphonomycin
- -hosphonomycin
- 0hosphonomycin
- pgosphonomycin
- pbosphonomycin
- pnosphonomycin
- pjosphonomycin
- puosphonomycin
- pyosphonomycin
- phisphonomycin
- phksphonomycin
- phlsphonomycin
- phpsphonomycin
- ph0sphonomycin
- ph9sphonomycin
- phoaphonomycin
- phozphonomycin
- phoxphonomycin
- phodphonomycin
Etymology of PHOSPHONOMYCIN
The word "Phosphonomycin" is derived from its chemical structure and composition. The prefix "phosphon-" refers to the presence of a phosphonate group (-PO3H2) within the compound. The suffix "-mycin" is commonly used in the nomenclature of antibiotics, suggesting that "Phosphonomycin" is a type of antibiotic. The word as a whole signifies a compound that contains a phosphonate group and exhibits antibiotic properties.
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