PHOSPHOGALACTOSE URIDYL TRANSFERASE Meaning and
Definition
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Phosphogalactose uridyl transferase, also known as Galactose-1-phosphate uridylyltransferase (GALT), is an important enzyme involved in the metabolism of galactose. It is encoded by the GALT gene in humans.
The enzyme facilitates the transfer of a uridine monophosphate (UMP) group from uridine triphosphate (UTP) to galactose-1-phosphate, resulting in the formation of glucose-1-phosphate and UDP-galactose. This reaction is essential for the conversion of galactose into glucose for further cellular utilization. UDP-galactose serves as a precursor in the synthesis of various carbohydrates and glycolipids involved in crucial biological processes.
The deficiency or malfunctioning of phosphogalactose uridyl transferase leads to a genetic disorder called galactosemia. This condition impairs the body's ability to properly metabolize galactose, causing its accumulation in the blood and tissues. As a consequence, individuals with galactosemia may experience a wide range of symptoms including liver damage, kidney problems, cataracts, and intellectual disability if not promptly diagnosed and managed through dietary modifications.
Phosphogalactose uridyl transferase is an essential enzyme for proper galactose metabolism, ensuring the efficient conversion of galactose to glucose and the synthesis of UDP-galactose. Its deficiency can have severe consequences, highlighting the importance of early diagnosis and appropriate treatment in individuals with galactosemia.
Common Misspellings for PHOSPHOGALACTOSE URIDYL TRANSFERASE
- ohosphogalactose uridyl transferase
- lhosphogalactose uridyl transferase
- -hosphogalactose uridyl transferase
- 0hosphogalactose uridyl transferase
- pgosphogalactose uridyl transferase
- pbosphogalactose uridyl transferase
- pnosphogalactose uridyl transferase
- pjosphogalactose uridyl transferase
- puosphogalactose uridyl transferase
- pyosphogalactose uridyl transferase
- phisphogalactose uridyl transferase
- phksphogalactose uridyl transferase
- phlsphogalactose uridyl transferase
- phpsphogalactose uridyl transferase
- ph0sphogalactose uridyl transferase
- ph9sphogalactose uridyl transferase
- phoaphogalactose uridyl transferase
- phozphogalactose uridyl transferase
- phoxphogalactose uridyl transferase
- phodphogalactose uridyl transferase
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