PASSIVE TRANSFER TEST Meaning and
Definition
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A Passive Transfer Test is a laboratory technique used to assess the presence and functionality of antibodies or immunoglobulins transferred from one organism to another. This test is primarily employed in the field of immunology to study immune responses and evaluate the effectiveness of immunization or disease resistance.
During a Passive Transfer Test, serum or purified antibodies from an immune or vaccinated donor organism are transferred into a susceptible or non-immune recipient organism. This transfer can occur through various routes such as injections or intravenous administration. The recipient organism is then exposed to a specific antigen, whether it is a pathogen or an artificial substance mimicking the pathogen.
The main objective of the test is to determine whether the transferred antibodies provide protection against the antigen and prevent infection or disease development. The recipient organism's immune response is monitored, measuring variables such as antibody levels, immune cell activation, or the presence of specific markers. By comparing the immune response of the recipient organism with and without the transferred antibodies, researchers can evaluate the efficacy of the transferred antibodies in preventing or reducing the effects of the antigen.
Passive Transfer Tests play a crucial role in vaccine development, evaluating the efficacy of antibody-based treatments or therapies, and studying the immune response to various pathogens. These tests provide valuable insights into the mechanisms of immune protection and help in the development of preventive and therapeutic strategies against infectious diseases.
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