How Do You Spell NUCLEOLIN?

1. Nucleolin is a protein that belongs to the nucleolus family. It is primarily localized in the nucleolus, which is a distinct region within the nucleus of eukaryotic cells. Nucleolin plays a crucial role in various cellular processes, particularly in the regulation of ribosome biogenesis and RNA metabolism.

   This protein is highly conserved across species and is known to be multifunctional. It is involved in the transcription and replication of DNA, as well as in the processing and maturation of pre-ribosomal RNA. Additionally, nucleolin is believed to participate in chromatin remodeling, telomere maintenance, and the modulation of cellular stress responses.

   The structure of nucleolin consists of several distinct domains, each contributing to its various functions. It contains acidic regions that facilitate interactions with histones, RNA, and DNA, as well as basic regions responsible for RNA binding. Nucleolin also has phosphorylation sites that regulate its activity and localization within the cell.

   Aberrant nucleolin expression has been associated with several pathological conditions, including cancer. It has been found to be upregulated in various cancer types, and its overexpression often correlates with tumor progression and poor prognosis. Due to its involvement in numerous cellular pathways, nucleolin has emerged as a potential therapeutic target for cancer treatment.

   In summary, nucleolin is a multifaceted protein primarily located in the nucleolus, responsible for regulating various cellular processes such as ribosome biogenesis and RNA metabolism. Its proper functioning is critical for maintaining cellular homeostasis, and its dysregulation can contribute to the development of diseases, including cancer.

2. Plastin, the substance of which the nucleolus is composed.

   A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.

Common Misspellings for NUCLEOLIN

The word "nucleolin" has its origin in two primary components: "nucleo-" and "-lin".

The prefix "nucleo-" derives from the Latin word "nucleus", meaning the central part or core. In biology, "nucleo-" typically pertains to structures or substances related to the nucleus of a cell.

The suffix "-lin" is commonly used to denote a protein. Many proteins have names ending in "-lin", indicating their classification in this particular molecular group.

Therefore, "nucleolin" is a combination of "nucleo-" referring to the nucleus and "-lin" representing a protein, ultimately implying a protein found in the nucleus of a cell.