NISSL BODIES Meaning and
Definition
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Nissl bodies, also known as Nissl substance or Nissl granules, are a prominent feature of neurons in the nervous system. These bodies are dense aggregations of rough endoplasmic reticulum (ER) found in the cell bodies, dendrites, and initial segments of axons of neurons. They are named after the German neurologist and psychiatrist Franz Nissl, who first described them.
Nissl bodies consist of stacks of flattened membranes called cisternae, which are packed with ribosomes responsible for protein synthesis. These granules are particularly abundant in actively functioning neurons that require high levels of protein production to maintain their metabolic processes and participate in synaptic transmission.
The main function of Nissl bodies is to synthesize proteins needed for the maintenance and functioning of neurons. They play a crucial role in producing neurotransmitters, receptors, and other proteins necessary for neuronal communication and cell survival.
While Nissl bodies primarily aid in protein synthesis, their presence also plays a significant diagnostic role in neuropathology. Changes in the appearance or distribution of Nissl bodies can indicate various neurological disorders such as Alzheimer's disease, Parkinson's disease, or neuronal injuries.
In conclusion, Nissl bodies are specialized structures in neurons responsible for protein synthesis. They are essential for the normal functioning and maintenance of neurons, and their appearance can provide valuable insights into the health of the nervous system.
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Tigroid or chromophile granules constituting the stainable substance or kinetoplasm of the nerve-cell.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
Common Misspellings for NISSL BODIES
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Etymology of NISSL BODIES
The term "Nissl bodies" is named after its discoverer, Franz Nissl, a German neurologist and psychiatrist. Franz Nissl actively researched and published in the late 19th and early 20th centuries. He studied the microscopic structure of nerve cells and their components, particularly in relation to neurodegenerative diseases. Nissl bodies, also known as Nissl substance or Nissl substance granules, are dense collections of rough endoplasmic reticulum (RER) found in the cell bodies of neurons. These granules contain ribosomes and are involved in protein synthesis. The term "Nissl bodies" was coined in recognition of Nissl's pioneering work in the field of cellular neuroscience.
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