GTP PHOSPHOHYDROLASES Meaning and
Definition
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GTP phosphohydrolases, also known as GTPases, are a group of enzymes that catalyze the hydrolysis of guanosine triphosphate (GTP) molecules to guanosine diphosphate (GDP) and inorganic phosphate (Pi). GTPases are ubiquitous in living organisms and are essential for a wide range of cellular processes, including signal transduction, protein synthesis, vesicle trafficking, and cell division.
The hydrolysis of GTP is a critical step in the regulation of GTPase activity, as it allows the switching between the active GTP-bound state and the inactive GDP-bound state of the GTPase. This dynamic cycling between the two states enables GTPases to function as molecular switches that control various cellular activities by interacting with other molecules and proteins.
GTP phosphohydrolases belong to the larger superfamily of P-loop NTPases, which are characterized by a conserved phosphate-binding motif called the P-loop. This motif is responsible for binding and coordinating the terminal phosphate groups of nucleotide triphosphates like GTP. GTPases typically possess a conserved GTPase domain that contains the P-loop motif, as well as other structural elements involved in nucleotide binding and hydrolysis.
GTPase activity is tightly regulated by various factors, such as GTPase-activating proteins (GAPs) that stimulate the GTP hydrolysis rate and guanine nucleotide exchange factors (GEFs) that promote the exchange of GDP for GTP, thus activating the GTPase. Dysregulation of GTP phosphohydrolases has been associated with several diseases, including cancer, neurodegenerative disorders, and immune system dysfunction.
In summary, GTP phosphoh
Common Misspellings for GTP PHOSPHOHYDROLASES
- ftp phosphohydrolases
- vtp phosphohydrolases
- btp phosphohydrolases
- htp phosphohydrolases
- ytp phosphohydrolases
- ttp phosphohydrolases
- grp phosphohydrolases
- gfp phosphohydrolases
- ggp phosphohydrolases
- gyp phosphohydrolases
- g6p phosphohydrolases
- g5p phosphohydrolases
- gto phosphohydrolases
- gtl phosphohydrolases
- gt- phosphohydrolases
- gt0 phosphohydrolases
- gtp ohosphohydrolases
- gtp lhosphohydrolases
- gtp -hosphohydrolases
- gtp 0hosphohydrolases
Etymology of GTP PHOSPHOHYDROLASES
The word "GTP Phosphohydrolases" is a compound term comprised of three components: GTP, phospho-, and hydrolases.
1. GTP: The abbreviation GTP stands for Guanosine Triphosphate. Guanosine is one of the four nucleotides found in DNA and RNA, while triphosphate refers to the three phosphate groups attached to the guanosine molecule. The term GTP specifically refers to this nucleotide compound.
2. Phospho-: The prefix "phospho-" in this context refers to the addition or involvement of phosphate groups in a chemical compound. It is derived from the Greek word "phosphoros" meaning "light-bringing", which is related to the luminescent properties of phosphorus compounds.
