AMYLOID BETA PROTEIN PRECURSOR Meaning and
Definition
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Amyloid beta protein precursor (APP) is a transmembrane protein - a large molecule composed of amino acids - that is primarily found in the brain. It is a crucial component in the production and accumulation of insoluble amyloid beta (Aβ) plaques, which are believed to play a significant role in the development and progression of Alzheimer's disease.
APP is involved in various physiological functions, including neuronal growth, survival, and repair. It is synthesized within neurons and then transported to the cell membrane. Under normal conditions, APP is cleaved by enzymes called secretases into smaller fragments, leading to the production of soluble fragments that are not harmful to brain cells. However, in certain circumstances, APP undergoes abnormal processing and is cleaved by secretases in a different way, resulting in the production of longer and stickier Aβ fragments.
These Aβ fragments tend to aggregate and form insoluble plaques in the brain, impairing the normal functioning of neurons and promoting neurodegeneration. The accumulation of amyloid plaques is a key pathological hallmark of Alzheimer's disease. Additionally, it is believed that the presence of these plaques triggers a cascade of events that contribute to the development of other characteristic features of the disease, such as neurofibrillary tangles and inflammation.
Research efforts have focused on understanding the role of APP in Alzheimer's disease and developing therapies aimed at preventing the abnormal processing of APP and reducing the accumulation of Aβ plaques.
Common Misspellings for AMYLOID BETA PROTEIN PRECURSOR
- zmyloid beta protein precursor
- smyloid beta protein precursor
- wmyloid beta protein precursor
- qmyloid beta protein precursor
- anyloid beta protein precursor
- akyloid beta protein precursor
- ajyloid beta protein precursor
- amtloid beta protein precursor
- amgloid beta protein precursor
- amhloid beta protein precursor
- amuloid beta protein precursor
- am7loid beta protein precursor
- am6loid beta protein precursor
- amykoid beta protein precursor
- amypoid beta protein precursor
- amyooid beta protein precursor
- amyliid beta protein precursor
- amylkid beta protein precursor
- amyllid beta protein precursor
- amylpid beta protein precursor
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