ADENOSINE DIPHOSPHORIBOSYLTRANSFERASE Meaning and
Definition
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Adenosine Diphosphoribosyltransferase (also known as ADP-ribose pyrophosphatase or ADPRT) is an enzyme that plays a crucial role in various cellular processes. It is a member of the transferase enzyme family and is involved in the synthesis of adenosine diphosphoribose (ADPR) from nicotinamide adenine dinucleotide (NAD+).
The enzyme ADPRT catalyzes the reaction where the phosphoryl group of ATP is transferred to the 1'-oxygen of the ribose moiety of NAD+. This results in the formation of ADPR, a molecule essential for the function of several enzymes, signaling pathways, and cellular processes. ADPRT is found in different tissues and organisms, ranging from bacteria to humans.
ADP-ribose pyrophosphatase is of particular importance in the regulation of DNA repair mechanisms, which are responsible for maintaining genomic stability. By producing ADPR, ADPRT plays a crucial role in activating poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair pathways such as base excision repair and single-strand break repair. Additionally, ADPRT also participates in the regulation of calcium signaling, cell cycle progression, transcriptional control, and apoptosis.
The study of ADPRT and its associated functions is essential for understanding the fundamental mechanisms of cellular processes, as well as potential therapeutic approaches for various diseases.
Common Misspellings for ADENOSINE DIPHOSPHORIBOSYLTRANSFERASE
- zdenosine diphosphoribosyltransferase
- sdenosine diphosphoribosyltransferase
- wdenosine diphosphoribosyltransferase
- qdenosine diphosphoribosyltransferase
- asenosine diphosphoribosyltransferase
- axenosine diphosphoribosyltransferase
- acenosine diphosphoribosyltransferase
- afenosine diphosphoribosyltransferase
- arenosine diphosphoribosyltransferase
- aeenosine diphosphoribosyltransferase
- adwnosine diphosphoribosyltransferase
- adsnosine diphosphoribosyltransferase
- addnosine diphosphoribosyltransferase
- adrnosine diphosphoribosyltransferase
- ad4nosine diphosphoribosyltransferase
- ad3nosine diphosphoribosyltransferase
- adebosine diphosphoribosyltransferase
- ademosine diphosphoribosyltransferase
- adejosine diphosphoribosyltransferase
- adehosine diphosphoribosyltransferase
Etymology of ADENOSINE DIPHOSPHORIBOSYLTRANSFERASE
The word "Adenosine Diphosphoribosyltransferase" has its etymology rooted in the Latin and Greek languages.
1. Adenosine: This term comes from the Greek word "adenos", meaning gland. It is derived from the Greek word "adēn", which means small gland or kernel.
2. Diphospho: "Di-" is a prefix derived from the Greek word "dis", meaning two or twice. "Phospho" is derived from the Greek word "phosphoros", which means light-bringing.
3. Ribosyl: This term comes from the sugar ribose, which is a component of RNA (Ribonucleic Acid). word "ribose" is derived from the Latin word "ribos", meaning pitch.
4. Transferase: This word is formed from the Latin term "transferre", which means to transfer or carry over.
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